Desmitificando un nombre. Surgical Residency workload, perceptions and educational value: implications for competency- based medical education , Eric Walser. Study on graphene-based nanocomposites with special magnetoresistance properties , Songlin Yang. Yotis DY. Post-activation potentiation induced by concentric contractions at three speeds in humans , Alexander Zero.
Adlan Alhashmi. The journey of a single polymer chain to a nanopore , Navid Afrasiabian. Measurement and modeling of micro residual stresses in pure zirconium and Zr The effect of free-stream turbulence on turbulent boundary layers and convective heat transfer from flat plates , Ivian Carolina Alfaia de Magalhaes. Targeting CD5 to enhance immune T cell activation and function in treatment of solid tumours , Faizah Alotaibi.
Providing Trauma and Violence Informed Care to Preservice Teachers: A look into perceived behaviours and self-efficacy when working with children impacted by interpersonal and structural violence , Christina Amico. Implementing a multi-segment foot model in a clinical setting to measure inter-segmental joint motions , Tahereh Amiri.
Developing a model to assess the contribution of cytokeratin expressing cells during multipotent stromal cell-induced islet regeneration , Brianna Ananthan. A longitudinal person-centred investigation of commitment in newcomers to the military , Brittney K.
Avusuglo WSA. Incipient deformation of small volumes of fcc metals , Mahdi Bagheripoor. Barker Odhiambo. Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition , Izabela Z. Characterizing putative sexually dimorphic effects of a propionic acid induced autism spectrum disorder phenotype in adult male and female rats , Katie C. Standing on the forefront of school mental health: Building upon capacity in teacher candidates through mental health literacy and trauma-and-violence-informed-care , Richelle L.
Implications of long non-coding RNAs in the pathogenesis of diabetic retinopathy: a novel epigenetic paradigm. Is Responsible Leadership Possible? The effects of legacy sulphur deposition on methylmercury production in northern peatlands; geochemical and biological considerations , Jennifer L. Determining geological controls on nutrient availability at different depths in the soils of the Pelee Island Winery , Lindsay M.
Andrew Braun. Becoming a cosmopolitan teacher: Empirical and theoretical inquires , James S. Niche segregation among three sympatric species of swallows in southern Ontario , Kaelyn H. Examining the environmental influences on physical activity among children in rural Northern Ontario , Brenton L G Button. An outcome-based statistical framework to select and optimize molecular clustering methods for infectious diseases , Connor Chato.
Equivariant cohomology for 2-torus actions and torus actions with compatible involutions , Sergio Chaves Ramirez. An 8-year longitudinal assessment of health-related quality of life in children with epilepsy , Emily Chemnitz.
Electronic and local structures of Pt-based bimetallic alloy and core-shell systems , Jiatang Chen. Renewable-energy resources, economic growth and their causal link , Yiyang Chen. Yield improvement of a plant-made antibody against Enterohemorrhagic E. Exploiting the immunomodulatory potentials of iNKT cells in sepsis and cancer.
The effect of pacing strategy on m rowing ergometer performance in well-trained male and female rowers , Ryan A. The experiences of Family Medicine teachers and Family Medicine residents in multimorbidity care and education , Julie A. The enactment of patient education for complex inpatients over the course of a stay in an interprofessional internal medicine inpatient unit , Talia Di Marco.
The development of bacterial magnetic resonance imaging for microbiota analyses , Sarah C. Reconstructing carbon dynamics of alpine and temperate zone lakes using stable isotopic analysis , Rebecca M. Reactive oxygen species damage and consequences for mitochondrial function in the hibernating thirteen-lined ground squirrel, Ictidomys tridecemlineatus , Brynne Duffy. Material evaluation and structural monitoring of early-age masonry structures , Kyle Dunphy.
What Do Students Say about Writing? T Empey. Effect of moving boundary on fluid flow , Kh Md Faisal. Advanced Search. Skip to main content. Other benefits include: publicity for research - authors of electronic theses become more widely known and their reputations are enhanced easy worldwide access to your theses for colleagues and collaborators easy worldwide access to theses for job and grant applications a raised profile for research institutions reduced costs at the point of graduation since there is no need to have multiple copies printed.
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Protein phosphorylation is the addition of phosphate groups at specific sites in the protein to help its proper folding. There is evidence that there are changes in protein phosphorylation in ALS patients. Intrinsically disordered regions are parts in some proteins that do not have a specific shape due to their high flexibility. This flexibility helps the protein perform its function and bind to many other proteins. The downside to this flexibility is that it renders the protein prone to misfolding.
Scientists have found that many of proteins misfolding in ALS have intrinsically disordered regions. In this thesis we explore the misfolding of Matrin3, a nuclear protein that becomes abnormally altered in ALS individuals. Matrin3 has many phosphorylation sites and two large intrinsically disordered regions, so we decided to study how these factors contribute to Matrin3 misfolding in ALS.
We began our studies in a yeast model, which allows us to isolate Matrin3 and test its toxicity and localization. Interestingly, we discovered that protein phosphorylation and one the intrinsically disordered regions plays a major role in Matrin3 toxicity. Thus, we speculate that altered protein phosphorylation and intrinsically disordered regions drive Matrin3 misfolding in ALS patients leading to motor neuron dysfunction. Electronic Thesis and Dissertation Repository.
Advanced Search. Skip to main content. Thesis Format Monograph. Abstract Amyotrophic Lateral Sclerosis ALS is a neurodegenerative disorder characterized by degeneration of upper and lower motor neurons in the brain and the spinal cord, respectively. We have also developed an ODE model and have carried out gene-level simulations to get more insight into the genetic repertoire of prophages.
The results of our ODE model and gene-level simulations are in agreement with prophage repertoire data. Bacteriophages are viral predators of bacteria. Upon infecting bacteria, bacteriophages either kill the host bacteria or enter a long-term genetic association with the bacterial host. The ability of bacteriophages to kill bacterial cells is used as a therapeutic strategy to cure bacterial infections, called phage therapy.
If the bacteriophage enters a long-term association with the host, the viral genome integrated into the host bacterial genome is called a prophage. In this investigation, using mathematical modeling approaches, we study the synergistic effects of phage therapy and antibiotics on bacterial biofilm colonies, the evolution of prophages and the genetic composition of prophages.
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